Down 3 kgs already. I've lost weight gradually because I am more active, eat less and am aiming to lose the 16 lbs I put on when I was on the drug . It occurs when your thyroid gland produces excessive thyroxine. Perinuclear for anti-neutrophil cytoplasmic antibodies (ANCA), cytoplasmic ANCA, ENA profile (anti-Sm, anti-RNP, anti-SS-A, anti-SS-B, anti-Jo-1, anti-SCL-70, anti-CENP B) and serology for trichinella were also negative except for positive double-stranded DNA (19, normal<10). On average, breastfeeding women . This is happening ALL the time in your body whether you realize it or not. Methimazole is a reason for the increasing weight of patients during hyperthyroidism treatment. Foods to Avoid if you Have Thyroid Problems: Ive found that these 10 foods cause the most problems for thyroid patients. Methimazole-induced myositis occurring independently of such reactions was rarely stated. Steer clear of unhealthy processed foods that are high in sodium, refined sugar and fat, which contribute to weight gain. You started estrogen hormone replacement therapy or birth control. Authors designed the study to assess the amount of weight gain and they also examined the effect of treatment method on weight gain risk. Having an understanding of how it works in your body will help you determine how to treat it. Its also well known that having low T3 (a side effect of taking methimazole) may lead to weight gain as well. Its been almost 2 mths now, and feel alot better with out taking as many pills . Some side effects may not be reported. Your healthcare provider will check your thyroid levels and adjust your dose as needed. Data sources include IBM Watson Micromedex (updated 1 May 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. In conclusion, methimazole is a relatively safe medication. Two weeks after stopping methimazole, the fever reappeared associated with left gluteal swelling and mild erythema over the involved area. Methimazole can also be used for functions no longer indexed on this remedy. It made me feel really sluggish but after removal of my thyroid last May I feel lots better and now only take levothyroxine daily. Not really, at least not for every person. Take the missed dose as soon as you remember. The fever subsided a few days later without additional therapy. Differential diagnosis of eosinophilic myositis. It took 7 months of being on methimazole was nasty side? Mary Frances McCullar in November 2022 (left) and in April 2023. Wholesomealive.com is reader-supported. Methimazole can absolutely cause weight gain and it does this by blocking thyroid function and activation in the tissues in your body. Your thyroid, when working properly, helps manage your weight. Other drugs may interact with methimazole, including prescription and over-the-counter medicines, vitamins, and herbal products. If you're taking treatment for stomach acid, your provider may need to increase the dosage of your Synthroid. The thyroid gland impacts our health in a number of ways. Two weeks later, he developed a febrile illness. Overdose symptoms may include nausea, vomiting, upset stomach, headache, joint pain, fever, itching, swelling, or pale skin and easy bruising or bleeding. The fever subsided. Will Taking Thyroid Medication Cause A Heart Attack? Incorporate enough calcium in your diet to keep bones strong. Preeclampsia, gestational hypertension, which can cause the kidneys and liver to fail, as well as growth problems for the fetus. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Animal studies do not always cross over perfectly with humans, but they can still act as useful tools that we can learn from. Although the positivity of the double-stranded DNA can point toward an underlying lupus that has been unrecognized, the reversibility of symptoms after stopping methimazole and the marked eosinophilia are characterizing this episode as a drug reaction. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Men gained on average 17.6 lbs and women gained about 12.1 lbs. Hyperthyroidism: a condition where the thyroid gland is overactive and produces too much thyroid hormone. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. She presented with hairless scars on her scalp. Data sources include IBM Watson Micromedex (updated 1 May 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. appropriate medical assistance immediately. Through thyroid hormones, every component of your metabolism regulates. I cant fit into my clothes now, which is not a morale booster If anyone has any advice or a similar experience, Id love to hear it! Effectively this makes you HYPOthyroid (at least in most cases). You may cause more harm than good if you adjust your medication in this way. Some of the more frequently reported adverse reactions have included skin rash, urticaria, nausea, loss of taste, and abnormal loss of hair. The chemical formula is C 4 H 6 N 2 S. Molecular weight is 114.16. Once you start treatment (whatever that may be) the goal of that therapy or medication is to block thyroid function. Methimazole doses are based on weight in children, and any changes may affect your child's dose. I-131 is the destructive form used to destroy thyroid tissue in the treatment of thyroid cancer and with an overactive thyroid.
He was started on propranolol 60 mg/day and methimazole 20 mg/day. It decreases the amount of thyroid hormone your body makes. Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA. In drug-induced lupus, the symptoms usually appear within a month of starting therapy. Methimazole-induced myositis is a rare clinical entity. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. A fourth suggested mechanism would be an immune-mediated reaction inducing a lupus-like syndrome (7). Firstly, the body is recovering from a disease that caused the body to lose about 10 kg when Hyperthyroidism was cured due to a regular diet and average hormone production. Hyperthyroidism results when the thyroid gland over-produces thyroid hormones. Egton Medical Information Systems Limited. Along with its needed effects, methimazole may cause some unwanted effects. Patients were treated for newly diagnosed hyperthyroidism using either anti-thyroid medications, radioactive iodine therapy (RAI) or a combination of the two methods between 2000 and 2014. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings chest pain chills cough dark urine difficulty in breathing dizziness or lightheadedness drowsiness feeling of constant movement of self or surroundings fever general feeling of discomfort, illness, or weakness headache hoarseness Methimazole prevents the thyroid gland from producing too much thyroid hormone. ABC7 Chicago 24/7 Stream. These medications act to block the thyroid but they are highly dose-dependent. Methimazole can lower blood cells that help your body fight infections and help your blood to clot. TRAB, thyroid receptor antibodies; GGT, gamma-glutamyl transpeptidase; SGOT, aspartate transaminase; SGPT, alanine aminotransferase; WBC, white blood count; ESR, erythrocyte sedimentation rate. During his stop in Antwerp, Belgium, he wrote, "I wanted to say that i'm not doing drugs, i've had a lot of people ask me about my weight loss and i'd suppose, performance on stage. feeling of constant movement of self or surroundings, general feeling of discomfort, illness, or weakness, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, feet, or lower legs, swollen, painful, or tender lymph glands in the neck, armpit, or groin, pain or discomfort in the chest, upper stomach, or throat. You're not losing weight because your thyroid is finally stable. Take your doses at regular intervals. They do better controlling their thyroid hormones using Regular L-Carnitine. 6. I am not diabetic. Thus, we describe an unusual case of myositis due to methimazole that was reversed after drug withdrawal. Learn more about the relationship between hyperthyroidism treatment and weight gain. #1. https://www.ncbi.nlm.nih.gov/pubmed/24692351, #2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817786/, #3. https://www.ncbi.nlm.nih.gov/gene/7173, #4. https://www.ncbi.nlm.nih.gov/pubmed/28759749, #5. https://www.ncbi.nlm.nih.gov/pubmed/22990640, #6. https://www.ncbi.nlm.nih.gov/pubmed/19341475, #7. https://www.ncbi.nlm.nih.gov/pubmed/19432125, #8. https://www.ncbi.nlm.nih.gov/pubmed/11531931, #9. https://www.ncbi.nlm.nih.gov/pubmed/12939927. (b) Dense mixed inflammatory cell infiltrate with associated myofiber necrosis and regeneration (white arrow). If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Muscle complaints are frequent in patients with thyroid disease. Thyrotoxic myopathy is painless, the creatine phosphokinase is usually normal, and the muscle biopsy findings are not specific, including marked muscle fiber degeneration and atrophy (1). She lost 21 pounds and her junk food cravings. Restart Medical LLC. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Methimazole is used to treat hyperthyroidism (overactive thyroid). While this medication may be prescribed for children for selected conditions, precautions do apply. Check with your doctor immediately if any of the following side effects occur while taking methimazole: Some side effects of methimazole may occur that usually do not need medical attention. The average weight gain in these patients ranges from around 10-15 pounds or an increase of 8.49 in BMI (a huge increase!). Rapid clinical and laboratory improvements were evident. Has anyone experienced this ?. Polymyositis after propylthiouracil treatment for hyperthyroidism, Carbimazole-related myositis in a Chinese woman, QJM: Monthly Journal of the Association of Physicians, Elevation of creatine kinase during medical treatment of Graves's disease, Murata K, Sugie K, Takamure M, Fujimoto T & Ueno S. 2003, Eosinophilic major basic protein and interleukin-5 in eosinophilic myositis, Wang LC, Tsai WY, Yang YH & Chiang BL. Methimazole, the main reason for increasing weight during treatment of Hyperthyroidism, causes about 10% of patients to gain weight during and after the treatment. Side effects may include fluid retention, weight gain, elevated blood sugar levels, increased blood pressure and mood swings. These side effects may go away during treatment as your body adjusts to the medicine. So if you are on these medications you will need to take a close look at your current dose to determine if you are taking too much or to see if you can reduce your dose. It is always possible to contract a disease in the world we live in. Do not stop taking this medication except on the advice of your care team. NOTE: This sheet is a summary. Weight loss is possible while taking Tapazole if you have a strategy. Follow all directions on your prescription label. The amount of weight gain was associated with the severity of hyperthyroidism at time of diagnosis and patients who had reported weight loss prior to treatment had more weight gain. Although not all of these side effects may occur, if they do occur they may need medical attention. Thereby, the onset of fever, rash, hepatitis, and myositis that were mild and subsided after methimazole withdrawal can be referred to a lupus-like syndrome. This can obviously be confusing for patients, but it doesnt have to be. Gained it back rather quickly after I got on methimazole. National Library of Medicine Registered in England and Wales. Mary Frances McCullar wanted to lose the weight she gained during the COVID pandemic. Question: What happens when you stop using Methimazole? It is also used before thyroid surgery or radioactive iodine treatment. the contents by NLM or the National Institutes of Health. loss of bladder control. So does it make sense that you can put someone on a thyroid blocker like methimazole and expect to perfectly balance thyroid hormone in the body? Some items may interact with your medicine. In our case, the temporal relationship between the myositis and the introduction of methimazole cannot be ignored. Try our Symptom Checker Got any other symptoms? I lost 5 pounds in 3 days, not doing any exercise and eating regularly. A second hypothesis is that Methimazoles sulfa moiety might have interaction. Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). It may not cover all possible information. In addition to methimazole binding to thyroglobulin without delay, direct inhibition of thyroglobulin itself has been proposed. Aim for 1,000mg per day for adults under the age of 50 and 1,200mg for adults over 50. No evidence of vasculitis or parasites was seen. Loosing muscle weight very typical of the first time around. Skip the missed dose if it is almost time for your next scheduled dose. Some of the important ones are below: Stop using Methimazole before proper treatment: If you stop taking Methimazole before Hyperthyroidism is cured, you will lose a lot of weight. So we know that this is not an isolated phenomenon, but how can it be? Replacement therapy means the goal is a TSH in the normal range and is the usual therapy. Question: How much weight did patients gain on using Methimazole? For example, some can increase your appetite, while others can decrease it. If it is almost time for your next dose, take only that dose. Three weeks ago my doctor had me discontinue the medication to see if I had gone into remission, and since then I cannot lose weight at all. Patients that were included in the study had at least 6 months of follow up after treatment, had a minimum of four recorded weight measurements and they had to have successful treatment of hyperthyroidism. How does Hyperthyroidism occur? A 29-year-old male patient who has been previously healthy, on no medications, presented for weight loss during the last 6 months. Do not take extra medicine to make up the missed dose. From undetectable TSH to now normal range. Call your doctor for medical advice about side effects. I just had my dose cut from 5mg to 2.5 mg, and am feeling well. However, it can also act as an aggressive substrate for that enzyme, with the result that it becomes iodinated itself and interferes with the iodination of thyroglobulin. Engage in high-intensity interval training to melt layers of fat. The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. Low thyroid levels (hypothyroidism)unusual weakness or fatigue, increased sensitivity to cold, constipation, hair loss, dry skin, weight gain, feelings of depression. Methimazole is an antithyroid medicine. not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in
Advertising on our site helps support our mission. I had the same weight gain (or weight recovery from GD) experience after taking MMI. Last updated on Jan 5, 2023. Tapazole (methimazole)." Like anything in life, we need to try and achieve a balance, and if the balance is tipped in favor of hypothyroidism over hyperthyroidism, then there may be negative consequences. It may be possible to manage these symptoms by taking a close look at your dose and altering your dose if that makes sense. BACKGROUND Eat dark green leafy vegetables like spinach and kale for a calcium boost. All rights reserved. 1Department of Endocrinology, Saint Georges University Medical Center, University of Balamand, Beirut, Lebanon, 2Department of Family Medicine, Saint Georges University Medical Center, University of Balamand, Beirut, Lebanon, 3Department of Infectious Diseases, Saint Georges University Medical Center, University of Balamand, Beirut, Lebanon, 4Department of General Surgery, Saint Georges University Medical Center, University of Balamand, Beirut, Lebanon, 5Department of Pathology, Saint Georges University Medical Center, University of Balamand, Beirut, Lebanon, 6Department of Gastroenterology, Saint Georges University Medical Center, University of Balamand, Beirut, Lebanon.
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