Verywell Health's content is for informational and educational purposes only. Brain Fog (anxiety, depression, ADHD), lots of medications. For example, in one study, researchers investigated the mood elevating effects of silymarin, a collection of phytochemicals extracted from milk thistle. However, there is no solid evidence that supports these claims. If you or anyone you know is living with obsessive compulsive disorder (OCD), proclaiming the symptoms of this mood disorder as debilitating is a vast understatement. OCD symptoms usually revolve around irrational fears, repeated thoughts, and compulsions. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Although rare, milk thistle may trigger a number of common and mild side effects. However, its currently unclear if it has the same beneficial effects in humans. Milk Thistle Tea: Benefits, Side Effects, and Dosage. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: A randomized, triple-blind, placebo-controlled clinical trial, By Soraiya Ebrahimpour Koujan, Bahram Pourghassem, Gargari Majid, Published February 15, 2015, Retrieved May 5, 2019, 8. https://www.ncbi.nlm.nih.gov/pubmed/28025940, Current Drug Targets, A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin, By Devi KP, Malar , Braidy , Nabavi , Nabavi, Published 2017, Retrieved May 5, 2019, 9. https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1964, Toxnet, Valerian Root, Reviewed by SRP on 9/9/2014, Retrieved May 5, 2019, 10. https://nccih.nih.gov/research/results/spotlight/040310.htm, National Center for Complementary and Integrative Health, Study Shows Chamomile Capsules Ease Anxiety Symptoms, Last Updated October 21, 2015, Retrieved May 5, 2019, 11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612440/, Evidence Based Complementary Medicine, Lavender and The Nervous System, Published March 14, 2013, By Peir Hossein Koulivand, Maryam Khaleghi Ghadiri, and Ali Gorji, Retrieved May 5, 2019, 12. https://www.webmd.com/vitamins/ai/ingredientmono-437/lemon-balm, WebMD.com, Lemon Balm, Retrieved May 5, 2019, Requirements for using and reposting articles. Cathy Wong is a nutritionist and wellness expert. Minerals for OCD Prasad RR, Paudel S, Raina K, Agarwal R. Silibinin and non-melanoma skin cancers. Learn to concoct simple home remedies with easy-to-grow medicinal herbs, Some are looking to alternative medicines to help prevent or treat diseases like cancer. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. Milk thistle can trigger allergic reactions. It is possibly effective in diabetes and indigestion (). While milk thistle is considered a noxious weed in various parts of the United States, it has little oral consumption value and is best absorbed in tablet or capsule supplement form, but can also be consumed as a tea or oral tincture. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). However, evidence suggests that milk thistle extracts might be useful in the treatment of mood disorders. National Center for Complementary and Integrative Health. Milk thistle (Silybum marianum) is a plant traditionally used as a liver tonic. 1982;17:51721. Milk thistle is sometimes used to treat skin conditions including mild psoriasis. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. One reported effect of milk thistle is that it can boost breast milk production in lactating mothers. When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-B) pathway. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. information submitted for this request. Advertising revenue supports our not-for-profit mission. Skip the missed dose if it is almost time for your next scheduled dose. Milk Thistle (and liver cleansing) has two workings: it supports the liver and it lowers the inactive rT3 in favour of the active T3. Dupuis ML, Conti F, Maselli A, et al. Do not give any herbal/health supplement to a child without medical advice. Milk thistle often is used as a galactalogue, a food or supplement that people who are chest feeding take to improve milk production. Not all possible interactions are listed in this product guide. Clipboard, Search History, and several other advanced features are temporarily unavailable. Milk thistle has been used as a traditional remedy for neurological conditions like Alzheimers and Parkinsons disease for over two thousand years (13). Dosing of milk thistle ranged from 150 mg twice a day to 300 mg twice a day. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. In one clinical trial, 60 people with benign polyps in the colon (which often develop into colon cancer) took a herbal blend with milk thistle, a flaxseed antioxidant, and oat fiber for 2 . One study questioned the benefits of milk thistle for liver diseases. A double-blind controlled study. Elsevier; 2021. https://www.clinicalkey.com. Milk thistle is not recommended for children. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Summary Milk thistle may increase breast milk production in women who are lactating, though very little research has been done to confirm its effects. Hepatology. These side effects may be mild or severe. UltraThistle, the highest potency milk thistle formula, has been scientifically proven to be up to 10x more absorbable and up to 20x more effective than other standardized milk thistle formulas. All rights reserved. eCollection 2023. Milk thistle (Silybum marianum) is said to have certain health benefits, including liver health, diabetes management, cancer treatment, and more. IBM Micromedex. These studies have also seen that milk thistle may be able to reduce the number of amyloid plaques in the brains of animals with Alzheimers disease (18, 19, 20). The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. FOIA Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. However, human studies are limited and havent yet shown any beneficial effects. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Research shows that the silymarin in milk thistle helps protect the liver from many industrial toxins, such as carbon tetrachloride. But experts say that the evidence isnt conclusive. Camini FC, Costa DC. Some, but not all, milk thistle supplements are vegan. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. Milk thistle is currently used for the treatment of toxin-induced liver injury, for its inhibition of progressive hepatic fibrosis and the prevention of cirrhosis, for its antifibrogenic effects in alcohol-induced cirrhosis and for modulation of insulin resistance. MeSH Mol Med Rep. 2016;13(4):3243-8. doi:10.3892/mmr.2016.4887, Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. Its unclear what benefits, if any, it may have in the body, but its sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. the unsubscribe link in the e-mail. Zhang Z, Wu H, Qi S, Tang Y, Qin C, Liu R, Zhang J, Cao Y, Gao X. Int J Environ Res Public Health. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Phytother Res. Some researchers have suggested milk thistle benefits when treating osteoporosis after menopause, and it's a commonly used supplement in the U.S. Milk thistle. Rev Diabet Stud. "It helps to clear out the toxins and nourish the organ," says Justice. It is not certain whether milk thistle is effective in treating any medical condition. Summary In animals, milk thistle has been shown to stimulate bone mineralization. There are other supplements that work similarly to milk thistle. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Milk thistle may be a useful complementary therapy to help manage type 2 diabetes. Accessed Oct. 30, 2020. However, many of the studies are small and have methodological flaws, which makes it difficult to give firm guidance on this supplement or confirm its effects (46). Therefore, it may be best to avoid milk thistle during these life stages. Combining silybin with phosphatidylcholine and other phospholipids enhances the absorption of milk thistle's active compounds, providing powerful liver health support. The best doses of milk thistle have not been established for any condition it may be used to treat. Abstract Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Thats an alarmingly high percentage, leaving roughly 1.1 million people of the 2.2 million OCD sufferers in the United States seeking alternative treatment options (2) and natural remedies. It can help prevent elevation of liver enzymes, which can be a side effect of the medication. Trigonella foenum-graecum(fenugreek)also is used for this reason. Milk thistle (PDQ): Health Professional Version. Get the facts on milk thistle for the liver. We comply with the HONcode standard for trustworthy health information. Facts & Comparisons eAnswers. https://www.wolterskluwercdi.com/facts-comparisons-online/. To provide you with the most relevant and helpful information, and understand which Pizzorono JE, et al., eds. To ensure quality and potency in your herbal remedies, why not grow your own? Some medications have been known to interact with milk thistle negatively. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. 5th ed. Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. HHS Vulnerability Disclosure, Help 2023 Jan 14;19:133-151. doi: 10.2147/NDT.S376380. Acne is a chronic inflammatory skin condition. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Careers. JAMA. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Milk thistle may be useful in treating liver disease, cancer, and diabetes. Its main functions include antioxidant . Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. People sometimes eat the stem and leaves of milk thistle in salads. It is not known whether milk thistle passes into breast milk or if it could harm a nursing baby. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . Someone please correct me if I'm wrong. However, as this is the only study, more high-quality research is needed. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. We encourage you to discuss any decisions about treatment or care with your health care provider. If you choose to use milk thistle, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. There's limited evidence, though, for the role of milk thistle in bone health. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Fried, M.; Navarro, V.; Afdhal, N. et al. It's also proven useful in treating skin that's been damaged by radiation during breast cancer treatment. 7 likes, 2 comments - lyndsey | nutrition + fertility + herbalism + birth (@rooted_in_ritual) on Instagram: " Ways to Prepare for Ovulation Ovulation is the . Milk thistle. Do not take milk thistle without medical advice if you are using a medication to treat any of the following conditions: any type of infection (including HIV, malaria, or tuberculosis); arthritis pain, occasional pain, or tension headaches (including Advil, Motrin, or Celebrex); heartburn or gastroesophageal reflux disease (GERD); high blood pressure, high cholesterol, or a heart condition; psoriasis, rheumatoid arthritis, or other autoimmune disorders; This list is not complete. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. 2. Moreover, its unclear whether milk thistle is well enough absorbed in people to allow adequate amounts to pass through the blood-brain barrier. Epub 2016 Dec 22. If you are a Mayo Clinic patient, this could Effects of Silybum marianum (L.) Gaertn. Matutino Santos P, Pereira Campos G, Nascimento C. Neuropsychiatr Dis Treat. Moreover, silibinin was able to attenuate the neuronal damage in the hippocampus of A1-42-injected rats. https://www.nccih.nih.gov/health/milk-thistle. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Not only does this help prevent cirrhoris, but may also be advantageous for those living with hepatitis or other liver diseases. Subjects were assessed with the National Institute of Mental Health Trichotillomania Severity Scale (primary outcome), the Massachusetts General Hospital Hair Pulling Scale, Clinical Global Impression scale, and measures of depression, anxiety, and psychosocial . Milk thistle might also help prevent insulin resistance and slow the growth of cancer,. Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. official website and that any information you provide is encrypted Silymarin: not just another antioxidant. People have traditionally used milk thistle for problems with the liver and gallbladder . Milk thistle has been an important natural remedy for centuries of folk medicine practitioners. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. health information, we will treat all of that information as protected health See additional information. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. Its been discovered that one of the compounds in milk thistle may work similarly to some diabetic medications by helping improve insulin sensitivity and decrease blood sugar (43). However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations (44). Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article. Additionally, the antioxidant and anti-inflammatory properties of milk thistle may also be useful for reducing the risk of developing diabetic complications like kidney disease (43). However, research is not conclusive on its uses. Milk thistle ( Silybum marianum) is an herbal remedy used mainly to protect and detoxify the liver. Phytomedicine. 5 Brain Supporting Supplements Youll Want In Your Medicine, According to the International OCD Foundation, selective serotonin reuptake inhibitor (SSRI), UltraThistle, the highest potency milk thistle formula, Review on the Chemistry and Neuroprotective Effects of Silymarin. Milk thistle contains compounds that may support skin, liver, and bone health and enhance weight loss. Just amazing and timely information at your fingertips. Can You Get Milk Thistle Naturally From Foods? More studies are needed before it can be determined how silymarin might be used to support people undergoing cancer treatment. Memorial Sloan-Kettering Cancer Center: About Herbs: Milk thistle., Natural Standard Patient Monograph: Milk thistle.. Clin Exp Pharmacol Physiol. Since milk thistle may lower blood sugar, people with diabetes should check with their doctor before taking the herb as it may make their blood sugar fall too low. a history of endometriosis or uterine fibroids. The following list is not exhaustive. Milk thistle may also be used for purposes not listed in this product guide. Our website services, content, and products are for informational purposes only. Osteoporosis is a disease caused by progressive bone loss. 2017 Apr;42(4):1073-1083. doi: 10.1007/s11064-016-2141-4. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. Quality and active ingredients in supplements may vary widely from maker to maker. A 2010 review by researchers found that black . Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. information highlighted below and resubmit the form. Milk thistle is taken by mouth most often for liver disorders, including liver damage caused by chemicals, alcohol, and chemotherapy, as well as liver damage caused by Amanita phalloides (death cap) mushroom poisoning, jaundice, chronic inflammatory liver disease, cirrhosis of the liver, and chronic hepatitis. While not dangerous, it can cause scars. Other studies looking at milk thistle for cirrhosis have found conflicting results. JIN_FK8R Please rate my stack I know I'm Fxxked up for now. You may opt-out of email communications at any time by clicking on This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. Summary The active ingredients in milk thistle have been shown in animals to improve the effects of some cancer treatments. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. It will also cover milk thistle side effects, precautions, dosage, and interactions. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 2018;8:65-74. doi:10.2147/PTT.S169333. Milk thistle can cause: Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating Itchiness Headache If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar.
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