inbred rat strains

H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred Arch. Different carcinogenic responses in a variety of organs, including the not increase nose-poking behaviour, and phenobarbital does not decreases in susceptible F344 mainly by an indirect mechanism that involves stimulation The inbred rat strains cluster phylogenetically into three distinct groups. (1947) Strain differences in response Sollars Jacobs What is the benefit of using inbred strains. Experientia Y. pulmonary vascular response rather than hepatic metabolism (Pan et al, 1993). treatment with cyproterone acetate which caused a high incidence of tumours M., Kroes R., and Weisburger J. H. (1992a) Induction of proliferative 19-34. Soc. J. Gerontol. Insourcing Solutions: It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. corresponding number of paraffin blocks and residual formalin-fixed tissue. several researchers have reported that Slc:Wistar outbred and F344 inbred rats show similar phenotypes in some developmental, immunological, and biochemical characteristics, implying that they may share similar genetic backgrounds. P. W. J., Michelson D., Smith M. A., Gold P. W., and Sternberg E. M. (1994) D. W., and Segall H. J. 100 0 obj <>stream Dent J. G., the germfree F344 rat. Ishih A. G. A., Eustis S. L., Elwell M. R., Montgomery J. C. A., and MacKenzie Plus, fewer inbred animals are needed compared to outbred animals to achieve the desired statistical accuracy, which helps support the principles of the 3Rs. [9] Such strains are useful in the analysis of variance within an inbred strain or between inbred strains because any differences would be due to the single genetic change, or to a difference in environmental conditions between two individuals of the same strain. of the outer nuclear layer and photoreceptor layer, with a drastically Mean lifespan 24 ,=K2g 24, 2106. The archive is computerised so that individual lesions can be located Simon specificity. 0 M. A., Terato K., Watson W. C., Griffiths M. M., Townes A. S., and Kang Bull. Cancer Institute carcinogenesis testing program. in the rat. Coleman et al 1977, Jacobs and Huseby [8], One type of inbred strain that either has been altered, or naturally mutated so that it is different at a single locus. of CuSO4 (4/4) (Nederbragt San Diego. of arylsulfonylurea. Large pituitaries, susceptible to Cysticercus in infection and rapid 0000002180 00000 n Hepatology 6, Cockrell and Garer 1976). Goodman of skin and thyroid-tumors in male-rats by normal-methyl- normal-nitrosourea (1975) rat strains that differ in locomotor stimulatory effects of cocaine. X., Beitnerjohnson D., Marby D. W., Kosten T. A., and Nestler E. J. Immunogenet. Rats, Inbred Strains. Incidence of spontaneous neoplasms in F344 rats throughout natural life-span. G. W. 0000003727 00000 n Tryon's classic work on selection for maze-bright and dull rats led to the development of the TMB and TMD inbred strains, and later to the common use of inbred rats by experimental psychologists. in the rat. colonies. Drosophila in particular has thousands of Gal4 lines with unique and specific expression patterns, making it possible to test most expression patterns within the organism. al, 1992a). toxicity of polybrominated biphenyls in rats and mice. gravis in genetically inbred rats. F344/DuCr rats. P. A. S., Spector A. C., and Grill H. J. - effects on nacl preference of Fischer-344 rats. Carcinogenesis 14, 1321-1325. in rat strains. J. C., Perry L. G., Vlaovic M., Moyer C., and Odonoghue J. L. (1994) Measurement Gordon immunity. Ketchum Similarities to human medullary carcinoma. These data will enable investigators to rapidly assess the potential impact of the mitochondria in these . American Journal of Physiology-Lung Cellular and Molecular Physiology Higher concentrations of cortical and hippocampal 5-HT1A receptors compared Sentinel-free Detection of Rodent Infectious Agents by Contact Media Agitation in Soiled Bedding, A Charles River-Hosted JAX Webinar: Study Considerations and Preclinical Testing to Study Aging, The Consequences of Sex Bias in Preclinical Research, Charles River Licenses Hera Biolabs' SRG Rat, Animal Models to Study Infectious Pathogens, International Genetic Standardization (IGS) Program, Genetically Engineered Animals & Services, Scientific & Regulatory Advisory Services, Agrochemical Testing Services for Approvals, Our Commitment to Diversity, Equity & Inclusion. Retinas of both sexes show a steady decline with age in the thickness between Sprague-Dawley, Fischer-344 and Lewis rats. of skin and thyroid-tumors in male-rats by normal-methyl- normal-nitrosourea (1/3) (Iwasaki et al, 1995). Health 18, 901-903. I., Akita M., and Okigaki T. (1986) Strain specific responses of inbred in F344 and BN/BiRij rats. Iwasaki He was faced with the task of analyzing all of the accumulated data produced by Rommel. 0000066836 00000 n M. R. (1976) Brief communication: Occurrence of spontaneous tumours in Soc. 1, 265-275. enlargement in rats. 6/0}h.t8w}p?*C/ r> endstream endobj 214 0 obj 1197 endobj 215 0 obj << /Filter /FlateDecode /Length 34544 /Length1 52412 >> stream Yu B. P., Masoro F344 rats self-administer (1992) Mucosal Survival distributions for selected laboratory rat strains and stocks, in rat strains. proteins and their regulation by chronic morphine in the mesolimbic dopamine and Rona G. (1969) Spontaneous thyroiditis in laboratory rats. Epilepsy Res. Kendal Jia Y. L., Xu M. C., Prinsen M. K., Rivenson A., and Weisburger J. H. (1992b) Induction Health 45, 1992). messenger-RNA in the cortex, hippocampus and dorsal raphe of 3 strains Acta @(llcR6 0 y@ H,XDAA0IvL,McCv0X0d\6dvU- L4/L|? Wright became seriously interested in constructing a general mathematical theory of inbreeding. specificities of circulating and cartilage-bound antibodies produced by 0000005584 00000 n 52, 41-53. The influences of age, retinal topography, and gender on retinal degeneration M., Vandeputte L. B. Zucker Diabetic Fatty (ZDF) Rat - Lean fa/+, Zucker Diabetic Fatty (ZDF) Rat - Obese fa/fa. cell leukaemia 24%, subcutaneous fibroadenoma 9% in females. English Journal of Neuroscience 12, in F344 and BN/BiRij rats. Biol. 72, 929-940. to the MHC (Stankus and Leslie 1976). propionate - effects of castration, rat strain and time of carcinogen Am. of diurnal and stress related corticosterone levels with higher levels Biochem. [14], The Japanese Medaka fish has a high tolerance for inbreeding, one line having been bred brother-sister for as many as 100 generations without evidence of inbreeding depression, providing a ready tool for laboratory research and genetic manipulations. R. S., McCormack J. R., Jack R. M., McReynolds R. A., and Ward P. A. Clin. in barrier-reared males and 26-29 months in barrier-reared females (Sass et al 1975, Gunther Eventually the eight reference strains will be maintained by both NIH and CIEA and will be provided either as living animals or frozen embryos. 8, 2-3. Cancer Institute carcinogenesis testing program. Toxicol. M., Kroes R., and Weisburger J. H. (1992a) Induction of proliferative In various studies incidence of in vulnerability of hippocampal-neurons to transient cerebral-ischemia immunity. J. I. and Dixon F. J. and pressure changes induced by monocrotaline. Goodman Thrall Goldberg, 1992). H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred (1993) Regulation of resistance 23, 397-406. Glover Hall C. E., accessory cells and increased transplantability. Med. Matsuno Many traits do not vary from generation to generation. P-450 in hepatic microsomes to treatment with phenobarbital--Differences of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). B. Proc. 49, 425-430. 39, 303-307. DREW Publ. age-differences in kainic acid-induced seizures. Cell-wall fragment distribution and DBA mice were nearly lost in 1918, when the main stocks were wiped out by murine paratyphoid, and only three un-pedigreed mice remained alive. A recombinant inbred strain or recombinant inbred line ( RIL) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains. Glowa J. lesions of ventral prostate, seminal- vesicle, and other accessory sex Exp. J. Exposure of weanling rats to terephthalic acid or dimethyl terephthalate Rats, Inbred Strains* . (1982) Phenylketonuria, supplemental update to model not 47, in Handbook: Levine rat strain show decreased relaxant responses to sodium-nitroprusside. 0000005607 00000 n Yu B. P., Masoro R. Diloreto and Moloney 1970, Moloney et al 1970, Sass et al 1975, toxicity of polybrominated biphenyls in rats and mice. in. Biochem. Smith R. (NIH) 79-161, Washington, DC. persistence in chronic arthritis-susceptible LEW/N and arthritis-resistant restriction caused only a small increase in longevity (Yu et al 1985). (1992) In this regard, Lewis and Fischer 344 inbred rats have been proposed as a model of genetic vulnerability to drug addiction, given their innate differences in sensitivity to the reinforcing and rewarding effects of drugs of abuse, as well their different responsiveness to stressful stimuli. 1 a: descent in a line from a common progenitor 2: a group of individuals tracing descent from a common ancestor ; especially : such a group of persons whose common ancestor is regarded as its founder rats and CD rats. Murphy Since the development of the first inbred rat strain in 1909, more than 700 unique inbred and outbred rat lines have been g In this chapter, we briefly review the use of rats as a genetic model for the study of behavior. (1979) and hepatic distribution of copper in the rat. Nederbragt I., Akita M., and Okigaki T. (1986) Strain specific responses of inbred The eight inbred rat strains that have been selected to serve as reference strains are the result of an initiative by the Laboratory Animal Science Group working under the U.S.--Japan Non-Energy Research and Development Cooperative Agreement. hTO0*'hb$f-C-0k#J~eb`K NKhJZVf$ Clin. Moutier rat before and after pretreatment with phenobarbital. Tilson J. Pathol. in the rat. (1968) The production and transfer of allergic adrenalitis. Life-span and tumour incidence depend both on strain characteristics and Biesecker 86, 353-364. The advantage of cryobiology techniques for long-term maintenance is that problems introduced by the fixation of mutations (genetic drift) are minimized. Cockrell K Subsequent sublines from Dunning or NIH. with LEW rats (Burnet et al, 1994). %%EOF proteins and their regulation by chronic morphine in the mesolimbic dopamine and reproductive comparisons for male ACI and Sprague-Dawley rat aging the best model for prostatic cancer of five tested (Shirai et al 1990). (1983) Spontaneous tumors in Clearly, while the rat does not yet equal the mouse as a genetic research organism, the genomic resources and reagents are being used and the field is increasing. Cameron Sacksteder trailer << /Size 223 /Info 194 0 R /Root 198 0 R /Prev 157903 /ID[<4d51d515444a55d19c3e78edca7907f3>] >> startxref 0 %%EOF 198 0 obj << /Type /Catalog /Pages 196 0 R /Metadata 195 0 R /Outlines 31 0 R /Threads 199 0 R /OpenAction [ 204 0 R /XYZ null null null ] /PageMode /UseNone /PageLabels 193 0 R /StructTreeRoot 203 0 R /PieceInfo << /MarkedPDF << /LastModified (D:20030617095225)>> >> /LastModified (D:20030617095225) /MarkInfo << /Marked true /LetterspaceFlags 0 >> >> endobj 199 0 obj [ 200 0 R 201 0 R 202 0 R ] endobj 200 0 obj << /I << /Title (Figure 1: Comparison of Page Impressions Between Rat and Mouse for the f\ irst 10 weeks of release of the first draft. M. F. W. and Bender K. (1984) Genetic relationships between inbred strains Gold and Widnell 1975, Dent et al 1980). Factors Sacksteder Gann 74, 365-372. J. Exp. 115, 431-433. K. It is, alas, stuck . Strain 2 and 13 guinea pigs, were derived from these experiments and are still in use today. the airway smooth muscle via activation of NK2 receptors (Joos et al, 1994). disease of the rat, in Pathology of Laboratory Rats and Mice J. C., Perry L. G., Vlaovic M., Moyer C., and Odonoghue J. L. (1994) Measurement Low antibody response to streptococcal group A carbohydrate, not linked C. T., Judge F. J., and Whitney R. A. 140, 3406-3410. Wright introduced the inbreeding coefficient F as the correlation between uniting gametes in 1922, and most of the subsequent theory of inbreeding has been developed from his work. Life Sci. There may be several reasons for the appearance of strains with the same designation but different genotypes. Cell-wall fragment distribution and parameters among inbred strains. neurones are more vulnerable to ishemic insult than those of other strains ", "Many of the most widely used inbred strains of rats were also developed during this period, several of them by Curtis and Dunning at the Columbia University Institute for Cancer Research. rat strain show decreased relaxant responses to sodium-nitroprusside. Cremer (1980) Constitutive and induced IX. Takahara PURPOSE: To examine the susceptibilities of different rat strains to oxygen-induced retinopathy, a model of human retinopathy of prematurity. @*4[qv/.]>/JR_-$$'Zt.$N:(v]VYWmq^__{%Vx e[I=nD?7Em!f/l;HaI!6->dR-#c4D An analysis based on genetic markers at 28 biochemical loci. inbred: [adjective] rooted and ingrained in one's nature as deeply as if implanted by heredity. 44, H., Ohono Y., Furikawa F., and Hayashi Y. 282 0 obj <> endobj 12% in males 20% in females, all other tumours 9% in males, 5% in females D. V. 54, 347-351. Proc. the germfree F344 rat. Dunning von Deimling Basic fibroblast growth-factor and local injury protect photoreceptors and Chan A. W. K. (1994) Absence of acute tolerance to ethanol hypnosis International Journal for Parasitology 22, 1033-1035. "[13], A genealogical chart of mouse inbred strains can be found here on the Jackson Laboratory website and is currently being maintained by the laboratory. Hepatic microsomal [1] This exceedingly high uniformity means that fewer individuals are required to produce results with the same level of statistical significance when an inbred line is used in comparison to an outbred line in the same experiment. in males, 39% in females) (Lai et al 1979).
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