Participants of this study received either a placebo or 300 milligrams of ashwagandha twice per day for eight weeks. Essential vitamins, minerals and amino acids that are involved in neurobiological function include: However, several of these have had mixed results in helping support depression treatment. It was concluded that participants from all five studies found improvements in their anxiety. Harvard Health Publishing states that other medications, supplements and your diet all have the potential to affect the way your body processes your antidepressants. . PLoS.One. Some medications, called sedatives, can also cause sleepiness and slowed breathing. 1998;60(2):173-178. Hydroxyzine has moderate interactions with at least 207 different drugs. The plan to ashwagandha blood pressure medication interaction enter the company was does blood pressure medication make you put on weight quietly implemented the one from Hebei do hypertension medications affect sexuality University has already started the procedure the Yinchuan University s Zhou Qitian also agreed, and the next step is to do the school work Inner Mongolia can probiotics lower . Indian J Exp Biol. View abstract. J Ethnopharmacol. Herbal supplements can strongly affect the body. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. Skinmed. In this investigation, participants took either a placebo or 240 milligrams per day of ashwagandha extract. Ashwagandha interacts with 623 drugs. Cooley K, Szczurko O, Perri D, et al. Similar results were reported in another study that examined ashwagandha's effect on attaining quality sleep. It is commonly used for stress. View abstract. Ashwagandha may increase thyroid hormone levels. Malhotra, C. L., Mehta, V. L., Prasad, K., and Das, P. K. Studies on Withania ashwagandha, Kaul. Third-party agencies like these confirm that supplements actually contain what they say they do, but they do not approve medical claims. ", Mayo Clinic: "Selective Serotonin Reuptake Inhibitors (SSRIs)", Cleveland Clinic: "Depression Medicines: Risks / Benefits", Shanghai Archives of Psychiatry: "Use of Antipsychotics in the Treatment of Depressive Disorders", Food and Drug Administration: "Vitamins and Minerals Chart", World Journal of Biological Chemistry: "Complexity of Vitamin E Metabolism", NCBI Bookshelf: "Depression in Adults With a Chronic Physical Health Problem: Treatment and Management", Journal of Medicine and Life: "Nutrition and Depression at the Forefront of Progress", Harvard Health Publishing: "Cytochrome P450 Enzymes and Psychiatric Drugs", Complementary Therapies in Medicine Journal: "Evaluation of the Efficacy of Withania Somnifera (Ashwagandha) Root Extract in Patients With Obsessive-Compulsive Disorder: A Randomized Double-Blind Placebo-Controlled Trial", Serotonin and norepinephrine reuptake inhibitors (SNRIs), Norepinephrine and dopamine reuptake inhibitors (NDRIs), Noncompetitive N-methyl-D-aspartate receptor antagonists. J Ethnopharmacol 1991;33:91-5. 2013;45(4):417-8. View abstract. ashwaganda ashwagandha (Withania somnifera) Entire Monograph Reported Uses Reported Doses Cautions Drug Interactions Adverse Reactions Synonyms Other Info Add to Interaction Check Bull Natl Res Cent. Malhotra, C. L., Mehta, V. L., Das, P. K., and Dhalla, N. S. Studies on Withania-ashwagandha, Kaul. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. If you consume something that isn't recommended, you could end up reducing the effectiveness of your medication or increasing the likelihood of side effects. The Journal of Psychiatry study reported that omega-3 fats and vitamin D are the two essential nutrients that are most likely to help reduce depression symptoms. Dietary supplements: what you need to know. Efficacy of Withania somnifera supplementation on adult's cognition and mood. Can You Take A Z-Pak If You Have A Penicillin Allergy? After eight weeks, statistically significant improvements were seen in both aerobic capacity and recovery for those who took ashwagandha. IV. Indian J Exp Biol. Indian J Psychol Med. Consult a doctor before taking any medication. View abstract. Int Ayurvedic Med J 2013;1(5):1-7. Efficacy of Withania somnifera supplementation on adult's cognition and mood. of signs you need emergency medical attention or call 911. A few commonly prescribed benzodiazepines are: Alprazolam (Xanax) Clonazepam (Klonopin) Diazepam (Valium) Lorazepam (Ativan) Vaishnavi, K., Saxena, N., Shah, N., Singh, R., Manjunath, K., Uthayakumar, M., Kanaujia, S. P., Kaul, S. C., Sekar, K., and Wadhwa, R. Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences. Diarrhea. Do not use this product if you are pregnant or plan to become pregnant soon. The April 2008 issue of "Therapeutic Drug Monitoring" notes that some herbal products interfere with methodology used to measure drug levels in a patient's bloodstream. Integr Cancer Ther. This information does not contain all possible interactions or adverse effects. Medically reviewed by Drugs.com. Doctors prescribe immunosuppressants for people with conditions such as rheumatoid arthritis, psoriasis and ulcerative colitis, and to prevent rejection of organ transplants. You will need to talk about the benefits and risks of using this natural product. Cureus. View abstract. Is this an emergency? These side effects are usually experienced on higher doses. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, et al. J Ayurveda Integr Med. Health Sci Rep 2022;5(4):e741. Take extra care if you are taking drugs to help with your thyroid. 1992;30(3):169-172. However, you should not stop taking any prescribed medication. Ashwagandha may interact with various medications. 2013;74(11):1076-83. Although, it's important to note that long-term studies have not been performed on ashwagandha. Interactions with other substances: ashwagandha may interact with certain medications, supplements, and herbs. Unlike people taking SSRIs who can consume most foods without issue, people taking MAOIs need to avoid foods rich in tyramine, a nonessential amino acid. Dosage: How Much Ashwagandha Should I Take? A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) Indian J Physiol Pharmacol. After 60 days, participants who took ashwagandha reported lower levels of stress and were also found to have reduced cortisol levels. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. View abstract. Lu, L., Liu, Y., Zhu, W., Shi, J., Liu, Y., Ling, W., and Kosten, T. R. Traditional medicine in the treatment of drug addiction. National Center for Complementary and Integrative Health. Moreover, researchers also noted several limitations of the studies included, such as the varying methods used to assess sleep quantity and quality. Of note, the benefits were strongest in those who took at least 600 milligrams per day of ashwagandha for at least eight weeks. PLoS One 2021;16(9):e0257843. 1981;19(3):245-249. Tumori 8-31-1994;80(4):306-308. Anyone with upcoming surgery should stop using ashwagandha at least two weeks prior. National Library of Medicines list Long-term safety studies on ashwagandha are lacking. Researchers from another review concluded that ashwagandha might be useful in conditions such as: Studies used in this review included human, animal, and lab research. Take extra care if you are taking iron supplements. The most common side effects include: Other less common side effects of ashwagandha include: If you experience side effects when taking ashwagandha, be sure to stop using it and seek advice from a healthcare provider. Available for Android and iOS devices. Be aware that antidepressants and vitamins typically work with each other the vitamins won't replace your medication. View abstract. J Ayurveda Integr Med. View abstract. Synthroid is not known to interact with these supplements. According to an August 2016 study in the Complementary Therapies in Medicine Journal, taking ashwagandha with antidepressants like SSRIs can be a safe, effective and healthy way of supporting your mental health. It's worth noting that a drawback of both these studies is that they were performed on small sample sizes. Since you don't mention any drugs in your question, we'll list some of the potential interactions below. Sedatives: Since ashwagandha can both energize and induce restorative sleep, it might negate or amplify the effect of other sedative drugs, especially the benzodiazepines. A total of 203 drugs are known to interact with levothyroxine . Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A. V. The effect of total alkaloids (ashwagandholine) on the central nervous system. A randomized double blind placebo controlled study of ashwagandha on generalized anxiety disorder. 2009;15(4):423-430. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. J Evid Based Complementary Altern Med. Additionally, ashwagandha may increase testosterone levels in the body. Select a condition to view a list of vitamins. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. Am J Drug Alcohol Abuse 2009;35(1):1-11. 2003;19(3):211-222. View abstract. Due to an overall lack of scientific evidence, there are no standard dosage guidelines for ashwagandha. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. An eight-week safety study found that taking 300 milligrams daily of ashwagandha was safe for both males and females. Sleep Sci. According to the Cleveland Clinic, there are six different types of medications commonly used to treat depression. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications. View abstract. Some barbiturates include phenobarbital, pentobarbital and secobarbital. ; Vomiting and nausea. View abstract. Underactive Thyroid. 2008;6:14. Phytother Res 1991;5:111-14. Can You Take Lyrica And Flexeril Together? View abstract. ashwagandha and guggul used for thyroid conditions and find out if they are beneficial. However, if you were to combine St. John's wort with antidepressants like SSRIs, you could end up with disastrous results. Ashwagandha is an evergreen shrub that grows in Asia and Africa. . This herbal medicine term means that this substance is thought to help the body respond to mental and physical stress and to restore normal emotional and physical body function. In rare cases, the use of ashwagandha may lead to liver damage. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Some people may need to avoid taking Ashwagandha, however, including those who: Ashwagandha might cause sleepiness and drowsiness. Its effect on arterial blood pressure in anaesthetized dogs. Staff, Cotellic With Turmeric And Black Pepper Interaction. This article provides a review of the potential uses of ashwagandha. Ashwagandha may help the body cope with stress. However, some adverse effects are generally associated with ashwagandha. 4. J Atten Disord 2010;14:281-91. Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial. Indian J Physiol Pharmacol. View abstract. Monitor your blood pressure closely. . Dasgupta A, Peterson A, Wells A, Actor JK. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. doi:10.1097/MD.0000000000017186, Pratte MA, Nanavati KB, Young V, Morley CP. Cureus. Take extra care driving and doing tasks that you need to be alert for while taking this product. In Ayurvedic medicine, ashwagandha has been used for centuries as an alternative treatment for anxiety. Chitre D, Nadkarni S, Jagtap N, et al. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. View abstract. Although ashwagandha is mainly considered safe, side effects may be possible. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. If you're taking antidepressants and vitamins at the same time, be aware of the ingredients in your vitamin supplements. View abstract. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. This dosing has also been associated with improvements in memory. View abstract. low blood sugar). J Ethnopharmacol. However, these results have not been proven in humans. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! View abstract. View abstract. Cancer Lett. Ashwagandha may also contain withanolides, which are thought to have anti-inflammatory and antioxidant properties. 2001;75(2-3):165-168. Therefore, it is recommended to consult with a healthcare professional before adding ashwagandha to a weight loss plan, especially if you have any underlying medical conditions or are taking any medications . People using ashwagandha for physical performance may need to take higher doses of up to 1,250 milligrams daily to see benefits. Fortunately, no cases resulted in liver failure, and all recovered. Ashwagandha. J Funct Morphol Kinesiol. 2021;18(2):183-226. doi:10.1080/19390211.2020.1741484, D'Cruz M, Andrade C. Potential clinical applications of Ashwagandha (Withania somnifera) in medicine and neuropsychiatry. Compared to those who took the placebo, participants who took ashwagandha were found to have better visual memory, learning, and attention. Skinmed. 1993;31(7):607-611. View abstract. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. One systematic review found just five human trials that studied ashwagandha as an anxiety treatment. Expert Rev Clin Pharmacol. Venkataraghavan S, Seshadri C, Sundaresan TP, and et al. J.Altern.Complement Med. View abstract. Gastrointestinal side effects including nausea, vomiting and diarrhoea. Therapeutic Research Faculty 2020. View abstract. Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. Some products may not mix well with other drugs or natural products. Ashwagandha interacts with several types of prescription medicine, so consult your health care provider before taking this herbal remedy. 2021 Nov 25;13(2):100510. When people can't obtain all of the nutrients the Food and Drug Administration recommends, they typically look into taking supplements. View abstract. Lower ashwagandha doses of 225 milligrams per day to 400 milligrams per day have been associated with perceived improvements in stress and anxiety. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. J Neurol Sci 2000;176:124-7. 2012;7(9):e44419. Evid Based Complement Alternat Med. root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. J Diet Suppl. Phytother Res 2022. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Safety and adverse events were also not well-reported in the studies used in the review. J Med Food 2022. For more information, read the "What else do I need to know?" section below. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). Medicine (Baltimore). 2020;40(4):825-829. View abstract. Indian J Exp Biol. When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S. Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. In general, Ashwagandha is thought to be safe when used in moderate amounts. 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Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. Some research has proven that this may indeed be true. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. View abstract. Liver damage. 8-19-2005;334(1):276-287. Ashwagandha has mild interactions with at least 29 different drugs. Animal research and one case study indicate that the herb might increase serum concentration of thyroid hormones, according to Ray Sahelian, a medical doctor who specializes in natural supplements. There are a variety of vitamins and minerals that are essential for good health. The exact type of antidepressant you're taking will determine which foods, vitamins and supplements you should or should not ingest. Nutrients. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. 2019;98(37):e17186. Front Pharmacol 2022;13:901710. Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. Researchers from a different study believe that withanone (Win), a bioactive substance found in ashwagandha, is to blame for the liver damage. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. Supplements that are similar to ashwagandha include: It's typically best to take just one supplement or herb at a time for a medical condition. Choudhary, M. I., Nawaz, S. A., ul-Haq, Z., Lodhi, M. A., Ghayur, M. N., Jalil, S., Riaz, N., Yousuf, S., Malik, A., Gilani, A. H., and ur-Rahman, A. Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. Examples of immunosuppressants include azathioprine, cyclosporine, mycophenolate, prednisone and corticosteroids. Xanax is in the drug class benzodiazepines. This herb used in alternative medicine may help reduce stress. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. You can also connect with Dr. Brian Staiger on LinkedIn. Certain antidepressants may not be compatible with herbs or other natural ingredients in these products. Avoid beer, wine, and mixed drinks (alcohol) while taking this product. Effect of a medicinal plant (Passiflora incarnataL) on sleep. View abstract. The liver damage never progressed to liver failure, and most cases were resolved within five months. J Obstet Gynaecol Res 2021. Nonetheless, additional large-scale, long-term studies would strengthen these findings. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patients specific and unique circumstances. 2019;11(10):2362. doi:10.3390/nu11102362, Zhu C, Zhang Y, Wang T, et al. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. 8-16-1995;95(1-2):189-193. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. This means they can cause drug-drug interactions, and they can have all the usual side effects and risks that pharmaceutical can have. What about black My Dr. put me on 500mg of cephalexin 3 times a day and 150mg of fluconazole. Headache. A recent study looked at the health claims and safety of ashwagandha and found that the herb has shown anticancer, anti-inflammatory, heart-protective, liver-protective, and immunomodulatory (able to change the immune system) actions. Usually ashwagandha is taken 1000 mg per day, for the course of 3 to 4 months. Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. View abstract. Anbalagan, K. and Sadique, J. Some symptoms of high thyroid hormone levels include fatigue, increased appetite, sweating, restlessness, diarrhea, hair loss, insomnia, itching and high blood pressure. Ashwagandha can also interact with some medications and affect how they work. Aerobic capacity and recovery were assessed for all participants throughout the study. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. However, SSRIs don't work for everyone, and other antidepressants work via different pathways in your body. No supplement is intended to treat, cure, or prevent disease. 2008;9(6):369-374. This information may not fit your specific health circumstances. These medications work in the brain by indirectly enhancing the action of a chemical in the brain called gamma-aminobutyric acid (GABA) a neurotransmitter that has a calming effect which helps lower anxiety levels. Within this specific study, participants were randomized to receive a placebo (sugar pill with no active ingredients), an ashwagandha dose of 250 milligrams (mg) per day or 600 milligrams per day. 2021;16(9):e0257843. doi:10.1002/brb3.1760, Adalier N, Parker H. Vitamin E, turmeric and saffron in treatment of Alzheimer's disease. After 30 days, those who took either dose of ashwagandha self-reported positive effects on their anxiety. A total of 525 drugs are known to interact with Xanax. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Staff. Commonly prescribed SSRIs include sertraline (brand name Zoloft), paroxetine (Paxil), fluoxetine (Prozac) and citalopram (Celexa). Taking it with drugs that increase levels of thyroid hormone (e.g. Take extra care if you are at a high risk for infection. Most reported drug interactions are based on the potential additive effectswhen combined with certain drugs (e.g. Information from this source is evidence-based and objective, and without commercial influence. By Mayo Clinic Staff Herbal supplements are natural, so they must be safe, right? Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. Cancer Lett 2000;148:9-17. DISCLAIMER: Currently this does not check for drug . Ashwagandha might cause sleepiness and slowed breathing. View abstract. Hello! Which is why it might lead to sleepiness and drowsiness with medications such as Wellburtin. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Ashwagandha might increase how much thyroid hormone the body produces. Ashwagandha may be able to help with insomnia. Biochem.Biophys.Res Commun. Evid Based Complement Alternat Med. It is recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha out of an abundance of caution. View abstract. Some people should avoid using ashwagandha due to safety concerns. Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. Curr Res Toxicol. J R Coll Physicians Edinb. People who are pregnant or breastfeeding should avoid using the herb, as not enough is known about its safety. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Among the five cases, ashwagandha dosing ranged from 450 to 1,350 milligrams daily. Acta Nerv Super 1990;32(1):1-5. Per the research, ashwagandha demonstrated small but significant benefits on overall sleep for those with insomnia. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Talk with a healthcare provider about the right ashwagandha dosage for your needs. View abstract. The study took place over 10 weeks, and participant results were assessed based on sleep onset latency, total sleep time, sleep efficiency, and wake after sleep onset. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. J Altern Complement Med. 2021;57:102642. doi:10.1016/j.ctim.2020.102642, Bjrnsson HK, Bjrnsson ES, Avula B, et al. Still, a seal of approval from one of these agencies is your best bet for supplement quality since dietary supplements and herbs are not regulated in the United States. Praveenkumar, V., Kuttan, R., and Kuttan, G. Chemoprotective action of Rasayanas against cyclosphamide toxicity. In 2020 and 2021, some people began using ashwagandha to diminish the harmful effects of COVID-19, although there is no evidence to support that use. Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. Read more: 15 Celebrities Who Struggle With Anxiety and Depression. https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. View abstract. We comply with the HONcode standard for trustworthy health information. Biogerontology. Ashwagandha is considered safe when taken daily for up to three months. I have it on my medical HelloPharmacist 2016;5(4):40. doi:10.3390/antiox5040040, Vitale KC, Hueglin S, Broad E. Tart cherry juice in athletes: a literature review and commentary. Mild Interactions of hydroxyzine include: ashwagandha; brimonidine; eucalyptus; nettle; sage; siberian ginseng; This information does not contain all possible interactions or adverse effects. View abstract. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study.
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